Endocrine Abstracts

Introduction: Limited data exist on testosterone and oxidative stress induction. The present study was undertaken to evaluate, in vitro, the role of physiological concentrations of androgens (testosterone-DHT) in modulating the pro-oxidant and antioxidant activity of intact endothelial cells.Materials and methods: EA.hy926 macroendothelial cells were cultured in DMEM phenol red free without FBS for 24 hours. Growth medium was replaced and then testostero...

Introduction: Graves’ disease (GD) is an autoimmune thyroiditis frequently associated with development of Graves’ orbitopathy (GO). As a consequence, patients with GO experience impairment of quality of life (QoL) and social function. The aim of our study was to assess quality of life in patients with GO.Methods: This is a single-center observational study in an outpatient clinic of autoimmune endocrinopathies at a Tertiary, General, Universi...

Introduction: Delayed diagnosis of a cardiovascular event is related with higher case-fatality rate in women as compared to men. In fact, accumulating evidence supports an association between the menopausal status and the development of cardiovascular disease (CVD). We aimed to assess the extent of subclinical vascular disorders in young, healthy postmenopausal women, with respect to the calculated cardiovascular risk.Methods: This cross-sectional study ...

Introduction: There is a great interest in the association of thyroid hormones and mood. Although it appears to be important interactions between the central regulation of mood and the thyroid axis, the effects of antidepressants and especially of selective serotonin reuptake inhibitors (SSRIs) remain ambiguous. We investigated the thyroid function in perimenopausal women suffering from depression.Material and methods: We examined 102 perimenopausal wome...

Introduction: Hot flashes and night sweating are the most common medical complaints in women during the menopausal transition and they are strongly associated with the presence of perimenopausal depression. The pathophysiology of hot flashes has not been elucidated. Peripheral vasodilation and increase in skin temperature observed in women with hot flashes might be induced by changes in brain neurotransmitters and instability in the hypothalamic thermoregulatory center due to ...

Background and aims: It is well recognized that insulin resistance and type 2 diabetes (T2DM) are associated with an increased risk for cardiovascular disease especially in women, while the role of sex steroids is still controversial. Women with polycystic ovary syndrome (PCOS) represent a unique biological model for the study of the impact of all these factors on cardiovascular system. We aimed to evaluate the degree of low-grade inflammation and atherosclerosis in premenopau...

Aim: The present study was designed in order to investigate the lipid profile, as well as LDL oxidizability in vitro, of female progeny (girls and young women) with positive family history of cardiovascular diseases (CVD) and/or hyperlipidemia.Patients and methods: In the present study, 30 healthy female subjects were recruited, aged 3 to 30 years old (mean±S.D. 14.4±8.02 years old). These subjects were progeny of families...

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder, affecting 5–10% of women of reproductive age. The underlying pathogenesis is complex and incompletely understood. There is evidence that gonadotropin and gonadotropin receptor action play a role in the pathogenesis of PCOS with genome wide association studies in PCOS also implicating altered gonadotropin action in the aetiology of PCOS. Furthermore, our recent studies have demonstrated that gonad...

Background: We previously showed that menopausal hormone therapy (MHT) favorably affects both bone density and microarchitecture with persistent benefit after its withdrawal (1). Looking for indirect factors contributing to bone effects, we investigated the relation between MHT and changes on fat and lean (muscular) tissue. Existing results on MHT and body composition are conflicting and large cohort studies are lacking.Material and methods: The OsteoLau...

Introduction: LMTK3 is an oncogenic Receptor Tyrosine Kinase (RTK) implicated in resistance to endocrine therapy in breast cancer. Initially, LMTK3 was described as a regulator of Estrogen Receptor alpha (ERα) since it was found able to protect it from ubiquitin-mediated proteasomal degradation. In a cohort of breast cancer (BC) patients (n>600), LMTK3 protein levels and intronic polymorphisms were significantly associated with disease-free and overall surviv...